Hydrochloric Acid → (R)-ethyl 6-iodo-4-oxo-1-(piperidin-3-ylmethyl)-1,4-dihydroquinoline-3-carboxylate

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Reaction Steps

To a solution of (S)-ethyl 1-((1-(tert-butoxycarbonyl)piperidin-3-yl)methyl)-6-iodo-4-oxo-1,4-dihydroquinoline-3-carboxylate (Intermediate 112, 2.47 g, 4.57 mmol, 1 equiv.) in dichloromethane (18 mL) was added 4 N hydrogen chloride (4.57 mL, 18.28 mmol, 4 equiv.). This was stirred at room temperature for 12 h. The precipitate was washed with diethyl ether and dried to provide (R)-ethyl 6-iodo-4-oxo-1-(piperidin-3-ylmethyl)-1,4-dihydroquinoline-3-carboxylate as a light yellow solid (2.1 g, >99%).

Provenance & Evidence