Hydrochloric Acid → HCID 44626933, compound

Participants

Reaction Steps

Hydrochloric acid (1M solution in Et2O, 19.4 mL) was added dropwise under N2 to a solution of (1S,5R)-3-(3-{[4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-4H-1,2,4-triazol-3-yl]thio}propyl)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hexane (Example 14, 9 g) in Et2O (anhydrous, 135 mL). The resulting suspension was allowed to stir at room temperature for 2 h. The solid was then filtered, washed with Et2O and dried in vacuo overnight to provide the title compound (8.9 g) as off white solid (y=92%).

Provenance & Evidence