Water → HCID 68487447, compound

Participants

Reaction Conditions

Reaction Steps

The optically active 6,6′-dimethyl-5,5′-dibromo-3,3′-di(t-butyl)-2,2′-biphenol obtained in Example 1 (1.06 g, optical purity: >99% ee, 2.2 mmol), toluene (5 ml) and trifluoromethanesulfonic acid (750 mg, 5 mmol) were mixed followed by stirring the entire volume for 1 hour at 5° C. Water (10 ml) and chloroform (20 ml) were then added to the reaction mixture followed by extraction and liquid separation. The organic phase was then washed with water and dried with anhydrous magnesium sulfate followed by distilling off the solvent under reduced pressure. N-hexane (10 ml) was added to the remaining slurry followed by stirring at room temperature, washing and filtering to obtain optically active 6,6′-dimethyl-5,5′-dibromo-2,2′-biphenol (761 mg, yield: 93%, optical purity: >99% ee).

Provenance & Evidence