HRID2062070

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(NC(=O)c1ccc2ccccc2c1OCc1ccc(OCC(F)(F)F)nc1)C(=O)O

HCID11648317

未命名化合物

结构：CCC(C)(NC(=O)c1ccc2ccccc2c1OCc1ccc(OCC(F)(F)F)nc1)C(=O)OC

HCID66701210

未命名化合物

PRODUCTS

生成物

结构：CCC(C)(NC(=O)c1ccc2ccccc2c1OCc1ccc(OCC(F)(F)F)nc1)C(=O)O

HCID23132816

未命名化合物

PROCEDURE

实验过程

2-Methyl-2-({1-[6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylmethoxy]-naphtha-lene-2-carbonyl}-amino)-butyric acid was prepared in similar manner as 2-methyl-2-({1-[6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylmethoxy]-naphthalene-2-carbonyl}-amino)-propionic acid (example 150) via 2-methyl-2-({1-[6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylmethoxy]-naphthalene-2-carbonyl}-amino)-butyric acid methyl ester (C25H25F3N2O5 (490.48), LCMS (ESI): 491.15 (MH+)).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a613fc7f443e494095f2c48d3da730ac
来源数据集: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08283479B2
来源说明: uspto-grants-2012_10

反应 SMILES

CC(NC(C1C=CC2C(=CC=CC=2)C=1OCC1C=NC(OCC(F)(F)F)=CC=1)=O)(C)C(O)=O.C[O:35][C:36](=[O:68])[C:37]([CH3:67])([NH:40][C:41]([C:43]1[CH:52]=[CH:51][C:50]2[C:45](=[CH:46][CH:47]=[CH:48][CH:49]=2)[C:44]=1[O:53][CH2:54][C:55]1[CH:56]=[N:57][C:58]([O:61][CH2:62][C:63]([F:66])([F:65])[F:64])=[CH:59][CH:60]=1)=[O:42])[CH2:38][CH3:39]>>[CH3:67][C:37]([NH:40][C:41]([C:43]1[CH:52]=[CH:51][C:50]2[C:45](=[CH:46][CH:47]=[CH:48][CH:49]=2)[C:44]=1[O:53][CH2:54][C:55]1[CH:56]=[N:57][C:58]([O:61][CH2:62][C:63]([F:66])([F:65])[F:64])=[CH:59][CH:60]=1)=[O:42])([CH2:38][CH3:39])[C:36]([OH:68])=[O:35]