HCID 58370108, compound → HCID 58370220, compound

HRID 2062081Notes

Reaction equation

S1C2C=CC=CC=2N=C1COC1C2C=C(F)C=CC=2SC=1C(NC(C)(C)C(O)=O)=O.C[O:32][C:33](=[O:62])[C:34]([NH:37][C:38]([C:40]1[S:44][C:43]2[CH:45]=[CH:46][C:47]([F:49])=[CH:48][C:42]=2[C:41]=1[O:50][CH2:51][C:52]1[CH:53]=[N:54][C:55]([C:58]([F:61])([F:60])[F:59])=[CH:56][CH:57]=1)=[O:39])([CH3:36])[CH3:35]>>[F:49][C:47]1[CH:46]=[CH:45][C:43]2[S:44][C:40]([C:38]([NH:37][C:34]([CH3:35])([CH3:36])[C:33]([OH:62])=[O:32])=[O:39])=[C:41]([O:50][CH2:51][C:52]3[CH:53]=[N:54][C:55]([C:58]([F:60])([F:59])[F:61])=[CH:56][CH:57]=3)[C:42]=2[CH:48]=1

Participants

Reactant 2

HCID 58370108HCID 58370108, compound

HCID 66701285HCID 66701285, compound

Product 1

HCID 58370220HCID 58370220, compound

Procedure

2-{[5-Fluoro-3-(6-trifluoromethyl-pyridin-3-ylmethoxy)-benzo[b]thio-phene-2-carbonyl]-amino}-2-methyl-propionic acid was prepared in similar manner as 2-{[3-(benzothiazol-2-ylmethoxy)-5-fluoro-benzo[b]thiophene-2-carbonyl]-amino}-2-methyl-propionic acid (example 158) via 2-{[5-fluoro-3-(6-trifluoromethyl-pyridin-3-ylmethoxy)-benzo[b]thio-phene-2-carbonyl]-amino}-2-methyl-propionic acid methyl ester (C21H18F4N2O4S (470.45), LCMS (ESI): 471.10 (MH+)).

Sources & evidence

ORD record: ord-69003cbb0c444013991df48c6c7492b4
Source dataset: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08283479B2

Reaction notes

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