HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium fluoride → HCID 66701212, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium fluoride | HCID 25953 | — |
| Reactant | trans-2-(4-Chlorophenyl)vinylboronic acid | HCID 642694 | — |
| Reactant | HCID 58370136 | HCID 58370136 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 66701212 | HCID 66701212 | 65.3% |
Reaction Steps
50 mg 2-[(1-bromo-naphthalene-2-carbonyl)amino]-2-methyl-propionic acid methyl ester, 49.5 mg tetrakis(triphenylphosphine)palladium (0), 28.7 mg trans-2-(4-chloro-phenyl)vinylboronic acid and 43 mg CsF were suspended in 1 ml of MeOH and 3 ml of dimethoxyethane, deoxygenated with Argon, and heated to 80° for 14 h. The reaction was filtered, purified by RP-HPLC and freeze-dried to give 38 mg of 2-({1-[(E)-2-(4-Chloro-phenyl)-vinyl]-naphthalene-2-carbonyl}-amino)-2-methyl-propionic acid methyl ester (65%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08283479B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-ffb146074db64869a8f79c3c9beb31a1 |
| Source note | uspto-grants-2012_10 |