HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 58370178, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Lithium hydroxide, monohydrate | HCID 168937 | — |
| Reactant | HCID 66701212 | HCID 66701212 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 58370178 | HCID 58370178 | 96% |
Reaction Steps
38 mg 2-({1-[(E)-2-(4-chloro-phenyl)-vinyl]-naphthalene-2-carbonyl}-amino)-2-methyl-propionic acid methyl ester were dissolved in 3 ml of MeOH and 1 ml of water was added. After addition of 5 mg of LiOH.H2O the reaction was stirred at room temperature for 14 h. Filtration of the crude mixture, RP-HPLC and freeze-drying gave 35 mg of 2-({1-[(E)-2-(4-Chloro-phenyl)-vinyl]-naphthalene-2-carbonyl}-amino)-2-methyl-propionic acid (96%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08283479B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-bfa6045183d647998e62283bb4c5ee88 |
| Source note | uspto-grants-2012_10 |