2-Amino-2-phenylethan-1-ol → (S)-Methyl 2-amino-2-methylbutanoate hydrochloride

HRID 2062104Notes

Reaction equation

HRID 2062104 reaction equation
[ClH:1].[CH3:2][O:3][C:4](=[O:10])[C@@:5]([NH2:9])([CH3:8])[CH2:6][CH3:7].C1C=CC([C@H](N)CO)=CC=1>>[ClH:1].[CH3:2][O:3][C:4](=[O:10])[C@:5]([NH2:9])([CH3:8])[CH2:6][CH3:7]

Participants

3

Reactant 2

HCID 1347972-Amino-2-phenylethan-1-olHCID 13018906(R)-2-Amino-2-methyl-butyric acid methyl ester hydrochloride

Product 1

HCID 44890825(S)-Methyl 2-amino-2-methylbutanoate hydrochloride

Procedure

(S)-2-Amino-2-methyl-butyric acid methyl ester hydrochloride was prepared in analogous manner to (R)-2-amino-2-methyl-butyric acid methyl ester hydrochloride using (S)-phenylglycinol.

Sources & evidence

ORD record
ord-137648d197044201876484cb08a5d961
Source dataset
uspto-grants-2012_10
Patent number
US08283479B2

Reaction notes

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