HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1'-Carbonyldiimidazole → (Benzo[d][1,3]dioxol-4-yl)methyl 1h-imidazole-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | (1,3-Dioxaindan-4-yl)methanol | HCID 2776187 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (Benzo[d][1,3]dioxol-4-yl)methyl 1h-imidazole-1-carboxylate | HCID 58010871 | 86.5% |
Reaction Steps
A solution of (benzo[d][1,3]dioxol-7-yl)methanol (2 g, 13.14 mmol) and di(1H-imidazol-1-yl)methanone (4.26 g, 26.28 mmol) in 20 mL CH2Cl2 was heated overnight at 50° C. The reaction was quenched with water, extracted with CH2Cl2, dried over Na2SO4, filtered, and concentrated. Purification via silica gel chromatography using 10-70% EtOAc in CH2Cl2 gave (benzo[d][1,3]dioxol-7-yl)methyl 1H-imidazole-1-carboxylate (2.8 g, 86%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08283354B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-52b0c7ee73a14b85a0f33982618ddcab |
| Source note | uspto-grants-2012_10 |