Isatoic Anhydride → Anthranilamide

Participants

Reaction Steps

Isatoic anhydride (40 g, 245 mmol) was suspended in 650 mL 1 N NH4OH (2.5 equiv) and stirred at room temperature for 3 days. The precipitate was filtered and washed with water. The product was then dissolved in THF, filtered, and concentrated to dryness. The product was dried by azeotropic distillation with toluene and washed with CH2Cl2 to yield 10.9 g (32.7%) of 2-amino-benzamide.

Provenance & Evidence