HCID 58010950, compound → HCID 58010966, compound

HRID 2062245Notes

Reaction equation

HRID 2062245 reaction equation
[O:1]1[CH2:5][CH2:4][CH:3]([CH2:6][O:7][C:8]([N:10]2[CH2:15][CH2:14][N:13](CC3C=CC=CC=3)[CH2:12][CH2:11]2)=[O:9])[CH2:2]1.[H][H]>C(O)C.[Pd]>[O:1]1[CH2:5][CH2:4][CH:3]([CH2:6][O:7][C:8]([N:10]2[CH2:11][CH2:12][NH:13][CH2:14][CH2:15]2)=[O:9])[CH2:2]1

Participants

5

Reactant 2

HCID 58010950HCID 58010950, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 58010966HCID 58010966, compoundYield 103.3%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

4-Benzyl-piperazine-1-carboxylic acid tetrahydro-furan-3-ylmethyl ester (11.0 g) was dissolved in 100 ml ethanol. Palladium on carbon (10% Pd/C, 0.5 g) was added, and a hydrogen atmosphere was applied overnight at room temperature. The solution was filtered through Celite to remove the catalyst, and the Celite cake was rinsed with 50 ml ethanol. The combined filtrates were evaporated to dryness to yield piperazine-1-carboxylic acid tetrahydro-furan-3-ylmethyl ester (8.0 g) as a colorless oil.

Workup

  1. filtrationThe solution was filtered through Celite
  2. customto remove the catalyst
  3. washthe Celite cake was rinsed with 50 ml ethanol
  4. customThe combined filtrates were evaporated to dryness

Sources & evidence

ORD record
ord-ac562c1ce92348b4909b2d60a0476abf
Source dataset
uspto-grants-2012_10
Patent number
US08283354B2

Reaction notes

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