HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Nipecotic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 1-((Tert-butoxy)carbonyl)piperidine-3-carboxylic acid | HCID 2735647 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Nipecotic Acid | HCID 4498 | — |
Reaction Steps
To a solution of 1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid (500 mg, 2.18 mmol) in CH2Cl2 (10 mL) was added TFA (5 ml). The reaction mixture was stirred for an hour. Excess TFA was removed under reduced pressure, and the piperidine-3-carboxylic acid was used without neutralization for the next step. LC/MS: m/z 1303 (M+H)+ at 0.35 min (10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08283354B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-b598706faa8c4c7599f927469040f71b |
| Source note | uspto-grants-2012_10 |