HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Acetate → 4-amino-8-(cyclopentyloxy)-7-methoxy-2H-chromen-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Acetate | HCID 517165 | — |
| Reactant | 8-(cyclopentyloxy)-4-hydroxy-7-methoxy-2H-chromen-2-one | HCID 77174792 | — |
| Solvent | M-Xylene | HCID 7929 | — |
| Product | 4-amino-8-(cyclopentyloxy)-7-methoxy-2H-chromen-2-one | HCID 77174793 | — |
Reaction Steps
A mixture of 8-(cyclopentyloxy)-4-hydroxy-7-methoxy-2H-chromen-2-one (450 mg, 1.63 mmol, Example 1, Step 2), ammonium acetate (3.0 g, 39 mmol), and anhydrous m-xylene (8 mL) was refluxed under N2. After 3 h, the reaction was concentrated and purified by silica gel chromatography (3:2→0:1; hexanes:ethyl acetate) to give 4-amino-8-(cyclopentyloxy)-7-methoxy-2H-chromen-2-one: MS (ESI): 275.9.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745646B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-04761b64a3d74a64b013bacdf263a064 |
| Source note | uspto-grants-2010_06 |