Ammonia → 6-Amino-3-methoxy-2-pyrazinecarboxamide

HRID 2063147Notes

Reaction equation

HRID 2063147 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([C:8](OC)=[O:9])[C:5]([O:12][CH3:13])=[N:4][CH:3]=1.[NH3:14]>CO>[NH2:1][C:2]1[N:7]=[C:6]([C:8]([NH2:14])=[O:9])[C:5]([O:12][CH3:13])=[N:4][CH:3]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 22662843Methyl 6-amino-3-methoxy-2-pyrazinecarboxylate

Product 1

HCID 226628026-Amino-3-methoxy-2-pyrazinecarboxamide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In 70 mL of methanol is dissolved 3.50 g of methyl 6-amino-3-methoxy-2-pyrazinecarboxylate. Gaseous ammonia is introduced to saturate the solution with ammonia. The solution is stirred at ambient temperature for 14 hours. The solvent is distilled off from the reaction mixture under reduced pressure to obtain 3.1 g of 6-amino-3-methoxy-2-pyrazinecarboxamide.

Workup

  1. concentrationto saturate the solution with ammonia
  2. distillationThe solvent is distilled off from the reaction mixture under reduced pressure

Sources & evidence

ORD record
ord-d6253dc31ef84896a1e16e8c6a29b2af
Source dataset
uspto-grants-2012_10
Patent number
USRE043748E1

Reaction notes

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