Ammonia → HCID 22674954, compound

HRID 2063149Notes

Reaction equation

HRID 2063149 reaction equation
[NH2:1][C:2]1[N:3]=[C:4]([O:12][CH3:13])[C:5]([C:8](OC)=[O:9])=[N:6][CH:7]=1.[NH3:14]>CO>[NH2:1][C:2]1[N:3]=[C:4]([O:12][CH3:13])[C:5]([C:8]([NH2:14])=[O:9])=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 222Ammonia2×HCID 22674965HCID 22674965, compound

Product 1

HCID 22674954HCID 22674954, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In 100 mL of methanol is suspended 1.96 g of methyl 5-amino-3-methoxy-2-pyrazinecarboxylate obtained according to the method described in literature (JP-A-50-105675). The resulting suspension is saturated with ammonia by introducing gaseous ammonia thereinto at −20° C. Then, the solution thus obtained is allowed to react at 95° C. for 24 hours in a stainless steel-made closed vessel. After cooling, the solvent is distilled off under reduced pressure to obtain 1.57 g of 5-amino-3-methoxy-2-pyrazinecarboxamide.

Workup

  1. customobtained
  2. customat −20° C
  3. customThen, the solution thus obtained
  4. custommade closed vessel
  5. temperatureAfter cooling
  6. distillationthe solvent is distilled off under reduced pressure

Sources & evidence

ORD record
ord-7b36af609e0e4783a792dafb87ef29d5
Source dataset
uspto-grants-2012_10
Patent number
USRE043748E1

Reaction notes

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