Ammonia → HCID 178513803, compound

HRID 2063154Notes

Reaction equation

HRID 2063154 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([C:8](OC)=[O:9])[C:5]([OH:12])=[N:4][CH:3]=1.[NH3:13]>>[Cl:1][C:2]1[N:7]=[C:6]([C:8]([NH2:13])=[O:9])[C:5]([OH:12])=[N:4][CH:3]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 178499099HCID 178499099, compound

Product 1

HCID 178513803HCID 178513803, compound

Procedure

In 5 mL of 25% aqueous ammonia is suspended 0.25 g of methyl 6-chloro-3-hydroxy-2-pyrazinecarboxylate obtained according to the method described in literature [J. Med. Chem., 285-287 (1969)]. The suspension is stirred at ambient temperature for 1 hour. The deposited crystals are collected by filtration to obtain 0.18 g of 6-chloro-3-hydroxy-2-pyrazinecarboxamide.

Workup

  1. customobtained
  2. filtrationThe deposited crystals are collected by filtration

Sources & evidence

ORD record
ord-db31d676a6514af6a0d96d6c166f07c0
Source dataset
uspto-grants-2012_10
Patent number
USRE043748E1

Reaction notes

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