Potassium Nitrate → HCID 178513826, compound

HRID 2063159Notes

Reaction equation

HRID 2063159 reaction equation
[OH:1][C:2]1[C:3]([C:8]([NH2:10])=[O:9])=[N:4][CH:5]=[CH:6][N:7]=1.[N+:11]([O-])([O-:13])=[O:12].[K+]>S(=O)(=O)(O)O.O>[OH:1][C:2]1[C:3]([C:8]([NH2:10])=[O:9])=[N:4][C:5]([N+:11]([O-:13])=[O:12])=[CH:6][N:7]=1

Participants

5

Reactant 2

HCID 24434Potassium NitrateHCID 178513804HCID 178513804, compound

Product 1

HCID 178513826HCID 178513826, compoundYield 46.3%

Reagents, catalysts & solvents 2

HCID 962WaterSolvent2×HCID 1118Sulfuric AcidSolvent

Conditions

Temperature
40 °C

Procedure

In 24 mL of concentrated sulfuric acid is suspended 4.00 g of 3-hydroxy-2-pyrazinecarboxamide. To the suspension is added 3.09 g of potassium nitrate under ice-cooling. The resulting mixture is stirred at 40° C. for 3 hours. The reaction mixture is poured into 240 mL of water, and the deposited crystals are collected by filtration. The crystals thus obtained are suspended in 80 mL of water and heated under reflux for 30 minutes. After cooling, the crystals are collected by filtration to obtain 2.45 g of 3-hydroxy-6-nitro-2-pyrazinecarboxamide.

Workup

  1. temperaturecooling
  2. filtrationthe deposited crystals are collected by filtration
  3. customThe crystals thus obtained
  4. temperatureheated
  5. temperatureunder reflux for 30 minutes
  6. temperatureAfter cooling
  7. filtrationthe crystals are collected by filtration

Sources & evidence

ORD record
ord-d95554f558404ca4a7162380e1809bbf
Source dataset
uspto-grants-2012_10
Patent number
USRE043748E1

Reaction notes

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