HuagongsheHuagongshe Chemistry Print Report · For research reference only
Naphthalene → Duloxetine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Naphthalene | HCID 931 | — |
| Reactant | 3-(N-Methylamino)-1-(2-thienyl)-1-propanol, (-)- | HCID 10095047 | — |
| Product | Duloxetine | HCID 60835 | — |
Reaction Steps
contacting the (S)—N-methyl-3-hydroxy-3-(2-thienyl)-1-propanamine with an activated naphthalene in a reaction mixture under conditions sufficient to produce (3S)—N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-yl-propan-1-amine (Duloxetine) having the structure of formula (VIII); and (e) recovering the (3S)—N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-yl-propan-1-amine from the reaction mixture.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288141B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-c6d391424f39420ca94f53de53dbc8a5 |
| Source note | uspto-grants-2012_10 |