反应详情

5 ml of concentrated sulfuric acid were added to 20.0 g (78.7 mmol) of 2-fluoro-3-methylthio-4-(trifluoromethyl)benzoic acid in 200 ml of methanol, and the mixture was heated under reflux until complete conversion had been achieved. The mixture was cooled and the solvent was removed. The residue was taken up in water, and the mixture was extracted twice with ethyl acetate. The combined organic phases were washed once with saturated aqueous NaHCO3 solution. Finally, the organic phase was dried and the filtrate was freed from the solvent. This gave 20.5 g of methyl 2-fluoro-3-methylthio-4-(trifluoromethyl)benzoate as residue.

1. temperaturethe mixture was heated
2. temperatureunder reflux until complete conversion
3. temperatureThe mixture was cooled
4. customthe solvent was removed
5. extractionthe mixture was extracted twice with ethyl acetate
6. washThe combined organic phases were washed once with saturated aqueous NaHCO3 solution
7. customFinally, the organic phase was dried