Thiomorpholine → HCID 178451268, compound

Participants

Reaction Steps

A solution of 3-BOC-aminopropyl bromide (3.07 g; 12.9 mmol) and thiamorpholine (2.6 mL; 25.8 mmol) in CH2Cl2 (25 mL) is heated at the reflux temperature for 24 h. The mixture is cooled at r.t., filtered, washed with water (2×50 mL), dried over Na2SO4 and evaporated to dryness in vacuum. Purification by flash chromatography on silica gel (eluent CHCl3/CH3OH 9:1) yields 1-(3-BOC-aminopropyl)-thiamorpholine (3.1 g; 11.96 mmol), as a transparent oil.

Provenance & Evidence