HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluoro-5-nitroaniline → 2-(3-Hydroxypyrrolidin-1-yl)-5-nitroaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluoro-5-nitroaniline | HCID 67785 | — |
| Reactant | 4-Hydroxypyrrolidine | HCID 98210 | — |
| Product | 2-(3-Hydroxypyrrolidin-1-yl)-5-nitroaniline | HCID 62918689 | 46.6% |
Reaction Steps
According to a process similar to that described in Example II-1, starting from 3 g (19.22 mmol) of 2-fluoro-5-nitroaniline and 1.76 ml (21.14 mmol) of 3-hydroxypyrrolidine, 2 g of expected compound are obtained in the form of a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288376B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-30346558b7254666b9ec366df0571cb7 |
| Source note | uspto-grants-2012_10 |