Hydrochloric Acid → (2S)-2-(4-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl)morpholine hydrochloride

Participants

Reaction Steps

To a solution of (2S)-tert-butyl 2-(4-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl)morpholine-4-carboxylate (intermediate 18, 20.5 g, 59.4 mmol) in ethyl acetate (50 ml) was added hydrogen chloride (4N) in ethyl acetate (200 ml) at room temperature and stirred for 3 hours. The solvent was evaporated under reduced pressure, and the precipitate was filtered, washed with ethyl acetate and dried under reduced pressure to afford (2S)-2-(4-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl)morpholine hydrochloride (intermediate 19, 16.7 g, 99%).

Provenance & Evidence