3-Oxetanone → (S)-3-(2-chloro-9-methyl-6-(3-methylmorpholino)-9H-purin-8-yl)oxetan-3-ol

Participants

Reaction Steps

This compound was prepared in an analogous fashion to (S)-4-(2-chloro-9-methyl-6-(3-methylmorpholino)-9H-purin-8-yl)tetrahydro-2H-pyran-4-ol, using 3-oxetanone as the starting material. 1H NMR (CDCl3, 400 MHz) δ ppm 5.35 (broad s, 2H), 5.15 (t, J=6.9 Hz, 2H), 4.96 (d, J=7.2 Hz, 2H), 4.00 (dd, J=11.2, 3 Hz, 1H), 3.84 (s, 3H), 3.81 to 3.71 (m, 2H), 3.59 (td, J=11.6, 2.7 Hz, 1H), 3.47 (broad s, 1H), 1.39 (d, J=6.8 Hz, 3H); LC-MS m/z (method B2)=340/342 [M+H]+, RT=1.59 min.

Provenance & Evidence