2,6-dichloro-9-ethyl-9H-purine → (S)-4-(2-chloro-9-ethyl-9H-purin-6-yl)-3-methylmorpholine

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Reaction Steps

The compound (f-4) was prepared in an analogous fashion to (S)-4-(2-chloro-9-methyl-9H-purin-6-yl)-3-methylmorpholine, using 2,6-dichloro-9-ethyl-9H-purine as the starting material. 1H NMR (CDCl3, 400 MHz) δ ppm 7.71 (s, 1H), 5.41 (broad s, 1H), 5.00 (broad s, 1H), 4.19 (q, J=7.4 Hz, 2H), 4.00 (dd, J=7.8, 3.6 Hz, 1H), 3.76 (m, 2H), 3.61 (td, J=11.6, 2.6 Hz, 1H), 3.48 (broad s, 1H), 1.48 (t, J=7.2 Hz, 3H), 1.41 (d, J=6.8 Hz, 3H); LCMS m/z (method A)=284 [M+H]+, RT=2.06 min.

Provenance & Evidence