(S)-4-(2-chloro-9-ethyl-8-iodo-9H-purin-6-yl)-3-methylmorpholine → (S)-4-(2-chloro-8-cyclopropyl-9-ethyl-9H-purin-6-yl)-3-methyl-morpholine

Participants

Reaction Steps

The compound (f-1) was prepared in an analogous fashion to (S)-4-(2-chloro-8-cyclopropyl-9-methyl-9H-purin-6-yl)-3-methylmorpholine, using (S)-4-(2-chloro-9-ethyl-8-iodo-9H-purin-6-yl)-3-methylmorpholine as the starting material. 1H NMR (CDCl3, 400 MHz) δ ppm 5.31 (broad s, 1H), 5.00 (broad s, 1H), 4.26 (q, J=7.2 Hz, 2H), 3.97 (dd, J=11.3, 3.4 Hz, 1H), 3.74 (m, 2H), 3.58 (td, J=12.2, 2.7, 1H), 3.43 (broad t, 1H), 1.92 (m, 1H), 1.41 (t, J=7.2 Hz, 3H), 1.34 (d, J=6.2 Hz, 3H), 1.12 (m, 2H), 1.06 (m, 2H); LC-MS m/z (method A)=322 [M+H]+, RT=2.81 min.

Provenance & Evidence