3-Oxetanone → (S)-3-(2-chloro-9-ethyl-6-(3-methylmorpholino)-9H-purin-8-yl)oxetan-3-ol

Participants

Reaction Steps

This compound (i-j) was prepared in an analogous fashion to (S)-4-(2-chloro-9-ethyl-6-(3-methylmorpholino)-9H-purin-8-yl)tetrahydro-2H-pyran-4-ol, using 3-oxetanone as the starting material. 1H NMR (CDCl3, 500 MHz) δ ppm 5.70 to 4.70 (broad s, 2H), 5.20 (dd, J=12.1 Hz, 7.2 Hz, 2H), 4.95 (d, J=7.2 Hz, 2H), 4.31 (q, J=7.1 Hz, 2H), 4.02 (dd, J=11.3, 3.2 Hz, 1H), 3.78 (dt, J=11.7 Hz, 7.2 Hz, 2H), 3.61 (td, J=11.9 Hz, 2.7 Hz, 1H), 3.47 (s, 2H), 1.46 (t, J=7.2 Hz, 3H), 1.41 (d, J=6.8 Hz, 3H); LC-MS m/z (method B2)=354/356 [M+H]+, RT=1.71 min.

Provenance & Evidence