HuagongsheHuagongshe Chemistry Print Report · For research reference only
Heptane → (S)-4-(2-chloro-9-ethyl-8-(3-fluorooxetan-3-yl)-9H-purin-6-yl)-3-methylmorpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Heptane | HCID 8900 | — |
| Reactant | (S)-3-(2-chloro-9-ethyl-6-(3-methylmorpholino)-9H-purin-8-yl)oxetan-3-ol | HCID 58222527 | — |
| Reactant | (S)-4-(2-chloro-8-(3-fluorooxetan-3-yl)-9-methyl-9H-pur-in-6-yl)-3-methylmorpholine | HCID 58222529 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | (S)-4-(2-chloro-9-ethyl-8-(3-fluorooxetan-3-yl)-9H-purin-6-yl)-3-methylmorpholine | HCID 58222543 | — |
Reaction Steps
This compound was prepared in an analogous fashion to (S)-4-(2-chloro-8-(3-fluorooxetan-3-yl)-9-methyl-9H-pur-in-6-yl)-3-methylmorpholine, using (S)-3-(2-chloro-9-ethyl-6-(3-methylmorpholino)-9H-purin-8-yl)oxetan-3-ol as the starting material. LC-MS m/z (method C)=356/358 [M+H]+, RT=2.62 min; TLC (1:1 heptane:ethyl acetate): Rf=0.58.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288381B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-b971940823f94e27a66bfb0cf7ebdc46 |
| Source note | uspto-grants-2012_10 |