HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 66713377, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Boc-L-Valine | HCID 83693 | — |
| Reactant | Benzyl piperazine-1-carboxylate | HCID 643495 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 66713377 | HCID 66713377 | — |
Reaction Steps
To a solution of Boc-(L)-Val-OH (2 g) in DCM (5 mL) was added DIPEA (4.7 mL) and HATU (5.2 g). After stirring at RT for 10 min, a solution of piperazine-1-carboxylic acid benzyl ester in DCM (5 mL) was added and the resulting reaction mixture was stirred at RT for 2 h. Water was added and the phases were separated. The org. phase was washed with brine, dried (MgSO4) and evaporated off to give 9.3 g of the desired compound as beige oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288385B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-d3e5682c0ff64ad8addb480f178f5c89 |
| Source note | uspto-grants-2012_10 |