4-(Trifluoromethyl)phenyl isocyanate → HCID 25252974, compound

Participants

Reaction Conditions

Reaction Steps

To a stirring solution of 1-isocyanato-4-(trifluoromethyl)benzene (46.3 mg, 0.2474 mmol) in 8 mL of CH2Cl2 at 0° C. was slowly added a solution of (R)-4-(4-chlorobenzyl)-3-(pyrrolidin-2-yl)-4H-1,2,4-triazole (0.050 g, 0.1903 mmol) in dichloromethane (2 mL). The resulting mixture was stirred 0° C. for 30 minutes, then at room temperature overnight. The reaction mixture was concentrated in vacuo. Flash chromatography purification ((Hex/EtOAc with 10% of MeOH) afforded the desired product (68 mg, 79.4%).

Provenance & Evidence