反应详情

To a solution of crude (3R,5R)-1-(((S)-7-(trifluoromethyl)chroman-4-yl)carbamoyl)-5-(4-(4-chlorobenzyl)-5-methyl-4H-1,2,4-triazol-3-yl)pyrrolidin-3-yl acetate from Step F (120 mg, 0.21 mmol) in aqueous MeOH (2.0 ml, 1:1 water:MeOH) was added potassium carbonated (116 mg, 0.84 mmol). The reaction mixture was stirred at room temperature for 1 h. The reaction mixture was concentrated and the residue dissolved in EtOAc, washed with 1N HCl and then concentrated. Preparative HPLC purification provided the desired compound as a white fluffy solid (47 mg, 72% over 3 steps).

1. concentrationThe reaction mixture was concentrated
2. dissolutionthe residue dissolved in EtOAc
3. washwashed with 1N HCl
4. concentrationconcentrated
5. customPreparative HPLC purification