Hydrazine → HCID 57650483, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (R)-tert-butyl 2-(2-(4-chlorobenzyl)-3-(dimethylamino)acryloyl)pyrrolidine-1-carboxylate (580 mg, 1.5 mmol) in ethanol (10 mL) was added hydrazine (480 mg, 15 mmol). The resulting solution was heated at 70° C. for 2 h and concentrated in vacuo. Purification of the resulting residue by silica gel column chromatography (hexanes/ethyl acetate gradient, 10-100% EtOAc) afforded (R)-tert-butyl 2-(4-(4-chlorobenzyl)-1H-pyrazol-5-yl)pyrrolidine-1-carboxylate (360 mg, 67%). LCMS: calculated: 365, found (MH+): 366.

Provenance & Evidence