HCID 86629197, compound → HCID 57650043, compound

Participants

Reaction Steps

A solution of (2R)-benzyl 2-(2-(carbonyl)-3-oxobutanoyl)pyrrolidine-1-carboxylate in TFA (50 mL) and dichloromethane (50 mL) was stirred at room temperature for 1 hr and then concentrated in vacuo. The resulting residue was purified by silica gel column chromatography (hexanes/ethyl acetate gradient, 10-100% EtOAc) to afford (R)-benzyl 2-(3-oxobutanoyl)pyrrolidine-1-carboxylate (2.1 g, 18% over two steps). LCMS: 6.9 min calculated: 289, found (MH+): 290.

Provenance & Evidence