4-(Trifluoromethyl)phenyl isocyanate → HCID 25252815, compound

Participants

Reaction Steps

To a solution of (R)-4-(4-chlorobenzyl)-3-methyl-5-(pyrrolidin-2-yl)isoxazole (20 mg, 0.07 mmol) in dichloromethane (2 mL) was added 1-isocyanato-4-(trifluoromethyl)benzene (13 mg, 0.07 mmol). The reaction mixture was stirred at room temperature for 10 min and concentrated in vacuo. Purification of the resulting residue by semi-preparative HPLC afforded (R)-2-(4-(4-chlorobenzyl)-3-methylisoxazol-5-yl)-N-(4-(trifluoromethyl)phenyl)pyrrolidine-1-carboxamide (20 mg, 62%).

Provenance & Evidence