HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2063498Generated: November 1, 2026
4-Chloro-2-fluoroaniline → HCID 57650482, compound
https://huagongshe.com/reaction/2063498
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Chloro-2-fluoroaniline | HCID 93898 | — |
| Reactant | 3-Cyclobutene-1,2-dione, 3,4-dimethoxy- | HCID 123227 | — |
| Reactant | 1140496-10-1 | HCID 68811484 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Diisopropylethylamine | HCID 81531 | — |
| Product | HCID 57650482 | HCID 57650482 | — |
Reaction Steps
Dimethoxycyclobutenedione (28 mg) and the 4-chloro-2-fluoroaniline (30 mg) were dissolved in methanol (1 ml) and DIEA (0.035 ml). The reaction was stirred at 75° C. overnight. (R)-4-(4-chlorobenzyl)-3-methyl-5-(pyrrolidin-2-yl)-4H-1,2,4-triazole hydrochloride (58 mg) was added and stirring and heating was continued overnight. Flash chromatography purification (0-10% methanol/DCM) afforded the desired product as residue (11 mg, 11%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08288371B2 |
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| Source dataset | uspto-grants-2012_10 |
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| ORD ID | ord-2348d00fa0294a20baea7e9931615711 |
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| Source note | uspto-grants-2012_10 |
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