N,N-bis(3-methylbutyl)-4-nitro-3-[(3-piperidin-1-ylpropyl)amino]benzamide → 4-amino-N,N-bis(3-methylbutyl)-3-[(3-piperidin-1-ylpropyl)amino]benzamide

HRID 2063506노트

반응식

HRID 2063506 반응식
[CH3:1][CH:2]([CH3:32])[CH2:3][CH2:4][N:5]([CH2:27][CH2:28][CH:29]([CH3:31])[CH3:30])[C:6](=[O:26])[C:7]1[CH:12]=[CH:11][C:10]([N+:13]([O-])=O)=[C:9]([NH:16][CH2:17][CH2:18][CH2:19][N:20]2[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]2)[CH:8]=1>C(OCC)(=O)C.C(O)C.[Pd]>[NH2:13][C:10]1[CH:11]=[CH:12][C:7]([C:6]([N:5]([CH2:27][CH2:28][CH:29]([CH3:30])[CH3:31])[CH2:4][CH2:3][CH:2]([CH3:1])[CH3:32])=[O:26])=[CH:8][C:9]=1[NH:16][CH2:17][CH2:18][CH2:19][N:20]1[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1

참가 물질

4

반응물 1

HCID 68446148N,N-bis(3-methylbutyl)-4-nitro-3-[(3-piperidin-1-ylpropyl)amino]benzamide

생성물 1

HCID 684463484-amino-N,N-bis(3-methylbutyl)-3-[(3-piperidin-1-ylpropyl)amino]benzamide

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 21584252Ethanol ethylacetate용매

반응 조건

온도
20 °C

실험 절차

N,N-bis(3-methylbutyl)-4-nitro-3-[(3-piperidin-1-ylpropyl)amino]benzamide (1 g) in solution in a mixture of ethyl acetate/ethanol 2:1 (100 ml) and 10% palladium on charcoal (100 mg) are introduced into an autoclave. After stirring for 3 hours under a hydrogen atmosphere (3 bars) at a temperature of approximately 20° C., the catalyst is eliminated by filtration on celite and the filtrate is concentrated under reduced pressure at 40° C. in order to produce the expected compound in the form of an oil (910 mg, 97% yield).

후처리

  1. additionare introduced into an autoclave
  2. filtrationthe catalyst is eliminated by filtration on celite
  3. concentrationthe filtrate is concentrated under reduced pressure at 40° C. in order

출처 및 근거

ORD 기록
ord-437331ae17034809897a0b7512c6a1ee
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08288395B2

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