HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 8-[1,4]-Diazepan-1-yl-6-isopropyl-quinoline dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-(6-Isopropyl-quinolin-8-yl)[1,4]-diazepan-1-carboxylic acid tert-butyl ester | HCID 59366163 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 8-[1,4]-Diazepan-1-yl-6-isopropyl-quinoline dihydrochloride | HCID 66890995 | 100% |
Reaction Steps
4-(6-Isopropyl-quinolin-8-yl)[1,4]-diazepan-1-carboxylic acid tert-butyl ester (1.3 g, 1.0 equiv) was dissolved in MeOH (5 mL) and 1.0 M HCl in 1,4-dioxane (10 mL) was added to the mixture. After stirring at room temperature for 1 hour, the mixture was concentrated to dryness to afford the title compound (1.2 g, 100%). MS (ES) m/z 270.1 (M+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288373B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-7580e192a3314386bfdb3ec179ac49dd |
| Source note | uspto-grants-2012_10 |