HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Chloride → HCID 67608818, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 1-Hydroxybenzotriazole hydrate | HCID 2796029 | — |
| Reactant | HCID 66623987 | HCID 66623987 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 67608818 | HCID 67608818 | 50.4% |
Reaction Steps
An N,N-dimethylformamide (1 mL) solution of the compound (10 mg) obtained in Example 157, ammonium chloride (5 mg), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (10 mg), 1-hydroxybenzotriazole monohydrate (7 mg) and triethylamine (0.05 mL) was stirred for 16 hours. The reaction liquid was concentrated under reduced pressure, and the precipitated solid was collected through filtration, washed with distilled water and ethyl acetate in that order, and dried to give the title compound as a yellow solid (4.2 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288396B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-88cf591718fd4b02b87ffb3faad8b896 |
| Source note | uspto-grants-2012_10 |