Methylhydrazine → 4-(1-Methylhydrazino)-2-(trifluoromethyl)quinazoline

HRID 2063589Notes

Reaction equation

HRID 2063589 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([C:12]([F:15])([F:14])[F:13])[N:3]=1.[CH3:16][NH:17][NH2:18]>ClCCl>[CH3:16][N:17]([C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([C:12]([F:15])([F:14])[F:13])[N:3]=1)[NH2:18]

Participants

4

Reactant 2

HCID 6061MethylhydrazineHCID 14754354-Chloro-2-(trifluoromethyl)quinazoline

Product 1

HCID 14718224-(1-Methylhydrazino)-2-(trifluoromethyl)quinazolineYield 96%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 4-chloro-2-(trifluoromethyl)quinazoline (8 g, 0.0344 mol) in dry dichloromethane (100 ml) under nitrogen was added methyl hydrazine (1.74 g, 0.037 mol) and the mixture was stirred at room temperature for 5 h. The reaction mixture was washed with water (2×100 ml), brine and dried. The solvent was removed under vacuum to afford 8 g (96%) of the titled compound as a yellow solid.

Workup

  1. washThe reaction mixture was washed with water (2×100 ml), brine
  2. customdried
  3. customThe solvent was removed under vacuum

Sources & evidence

ORD record
ord-ac6e724e109f4877ab7d535c312d1d66
Source dataset
uspto-grants-2012_10
Patent number
US08288398B2

Reaction notes

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