反应详情

[6-(2-Methoxy-phenyl)-pyrimidin-4-yl]-hydrazine (500 mg, 2.3 mmol) and 4-dimethylaminoacetophenone (380 mg, 2.3 mmol) were dissolved in 4 mL of ethanol. The resultant reaction mixture was heated in the microwave (CEM Discover, 135 C, QuickTest Method) for 3 hours. The reaction mixture was cooled to room temperature and after standing for three days yellow crystals formed. The crystalline solid was isolated by filtration and dried in vacuo to yield 580 mg (70%) of the title compound. HPLC Purity: 93%.

1. customThe resultant reaction mixture
2. temperaturewas heated in the microwave (CEM Discover, 135 C, QuickTest Method) for 3 hours
3. customyellow crystals formed
4. customThe crystalline solid was isolated by filtration
5. customdried in vacuo