5-bromo-2-(4-methyl-1H-imidazol-1-yl)benzonitrile → HCID 59324064, compound

HRID 2063644Notes

Reaction equation

HRID 2063644 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([N:10]2[CH:14]=[C:13]([CH3:15])[N:12]=[CH:11]2)=[C:6]([CH:9]=1)[C:7]#[N:8].[F:16][C:17]1[CH:22]=[CH:21][C:20]([N:23]2[C:27]([CH3:28])=[N:26][C:25]([NH2:29])=[N:24]2)=[CH:19][CH:18]=1>>[F:16][C:17]1[CH:18]=[CH:19][C:20]([N:23]2[C:27]([CH3:28])=[N:26][C:25]([NH:29][C:2]3[CH:3]=[CH:4][C:5]([N:10]4[CH:14]=[C:13]([CH3:15])[N:12]=[CH:11]4)=[C:6]([CH:9]=3)[C:7]#[N:8])=[N:24]2)=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 669615175-bromo-2-(4-methyl-1H-imidazol-1-yl)benzonitrileHCID 67378141HCID 67378141, compound

Product 1

HCID 59324064HCID 59324064, compound

Procedure

Prepared in analogy to example 1b) starting with 5-bromo-2-(4-methyl-imidazol-1-yl)-benzonitrile and 1-(4-fluoro-phenyl)-5-methyl-1H-[1,2,4]triazol-3-ylamine (prepared in analogy to Gazzetta Chimica Italiana 29, 105 (1899)). The title compound was obtained as a slightly brownish solid (Yield=24%). MS ISP (m/e): 374.1 (100) [(M+H)+].

Workup

  1. customPrepared in analogy to example 1b)

Sources & evidence

ORD record
ord-0d1230f6646a4580a814842efd4113df
Source dataset
uspto-grants-2012_10
Patent number
US08288403B2

Reaction notes

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