HCID 64120767, compound → 2-(4-Methyl-imidazol-1-yl)-5-[1-(1-phenyl-ethyl)-1H-[1,2,4]triazol-3-ylamino]-benzonitrile

HRID 2063647Notes

Reaction equation

HRID 2063647 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([N:10]2[CH:14]=[C:13]([CH3:15])[N:12]=[CH:11]2)=[C:6]([CH:9]=1)[C:7]#[N:8].[C:16]1([CH:22]([N:24]2[CH:28]=[N:27][C:26]([NH2:29])=[N:25]2)[CH3:23])[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[CH3:15][C:13]1[N:12]=[CH:11][N:10]([C:5]2[CH:4]=[CH:3][C:2]([NH:29][C:26]3[N:27]=[CH:28][N:24]([CH:22]([C:16]4[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=4)[CH3:23])[N:25]=3)=[CH:9][C:6]=2[C:7]#[N:8])[CH:14]=1

Participants

3

Reactant 2

HCID 64120767HCID 64120767, compoundHCID 669615175-bromo-2-(4-methyl-1H-imidazol-1-yl)benzonitrile

Product 1

HCID 462160932-(4-Methyl-imidazol-1-yl)-5-[1-(1-phenyl-ethyl)-1H-[1,2,4]triazol-3-ylamino]-benzonitrile

Procedure

Prepared in analogy to example 1b) starting with 5-bromo-2-(4-methyl-imidazol-1-yl)-benzonitrile and 1-(1-phenyl-ethyl)-1H-[1,2,4]triazol-3-ylamine. The title compound was obtained as a yellowish solid (Yield=48%). MS ISP (m/e): 370.2 (100) [(M+H)+].

Workup

  1. customPrepared in analogy to example 1b)

Sources & evidence

ORD record
ord-ad03001c928844d9b11d25d99cccb75b
Source dataset
uspto-grants-2012_10
Patent number
US08288403B2

Reaction notes

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