4-Fluorobenzyl bromide → 1-[(4-fluorophenyl)methyl]pyrazol-3-amine

HRID 2063648Notes

Reaction equation

HRID 2063648 reaction equation
[NH2:1][C:2]1[CH:6]=[CH:5][NH:4][N:3]=1.[F:7][C:8]1[CH:15]=[CH:14][C:11]([CH2:12]Br)=[CH:10][CH:9]=1>>[F:7][C:8]1[CH:15]=[CH:14][C:11]([CH2:12][N:4]2[CH:5]=[CH:6][C:2]([NH2:1])=[N:3]2)=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 680214-Fluorobenzyl bromideHCID 178418806HCID 178418806, compound

Product 1

HCID 5732811-[(4-fluorophenyl)methyl]pyrazol-3-amine

Procedure

Prepared in analogy to example 10a) starting with 3-amino-1H-pyrazole and 4-fluorobenzylbromide. The title compound was obtained as a colorless solid (Yield=34%). MS ISP (m/e): 192.2 (100) [(M+H)+].

Workup

  1. customPrepared in analogy to example 10a)

Sources & evidence

ORD record
ord-1eb8002a310c4f298f00498d0cff41ae
Source dataset
uspto-grants-2012_10
Patent number
US08288403B2

Reaction notes

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