1-[(4-fluorophenyl)methyl]pyrazol-3-amine → HCID 46216094, compound

HRID 2063649Notes

Reaction equation

HRID 2063649 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([N:10]2[CH:14]=[C:13]([CH3:15])[N:12]=[CH:11]2)=[C:6]([CH:9]=1)[C:7]#[N:8].[F:16][C:17]1[CH:29]=[CH:28][C:20]([CH2:21][N:22]2[CH:26]=[CH:25][C:24]([NH2:27])=[N:23]2)=[CH:19][CH:18]=1>>[F:16][C:17]1[CH:29]=[CH:28][C:20]([CH2:21][N:22]2[CH:26]=[CH:25][C:24]([NH:27][C:2]3[CH:3]=[CH:4][C:5]([N:10]4[CH:14]=[C:13]([CH3:15])[N:12]=[CH:11]4)=[C:6]([CH:9]=3)[C:7]#[N:8])=[N:23]2)=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 5732811-[(4-fluorophenyl)methyl]pyrazol-3-amineHCID 669615175-bromo-2-(4-methyl-1H-imidazol-1-yl)benzonitrile

Product 1

HCID 46216094HCID 46216094, compound

Procedure

Prepared in analogy to example 1b) starting with 5-bromo-2-(4-methyl-imidazol-1-yl)-benzonitrile and 1-(4-fluoro-benzyl)-1H-pyrazol-3-ylamine. The title compound was obtained as a yellowish oil (Yield=75%). MS ISP (m/e): 373.2 (100) [(M+H)+].

Workup

  1. customPrepared in analogy to example 1b)

Sources & evidence

ORD record
ord-fd0a07ef904a460fb59adab7ff91591d
Source dataset
uspto-grants-2012_10
Patent number
US08288403B2

Reaction notes

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