1-(2-trifluoromethyl-phenyl)-1H-[1,2,4]triazol-3-ylamine → 2-(4-Methyl-imidazol-1-yl)-5-[1-(2-trifluoromethyl-phenyl)-1H-[1,2,4]triazol-3-ylamino]-benzonitrile

HRID 2063654Notes

Reaction equation

HRID 2063654 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([N:10]2[CH:14]=[C:13]([CH3:15])[N:12]=[CH:11]2)=[C:6]([CH:9]=1)[C:7]#[N:8].[F:16][C:17]([F:31])([F:30])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[N:24]1[CH:28]=[N:27][C:26]([NH2:29])=[N:25]1>>[CH3:15][C:13]1[N:12]=[CH:11][N:10]([C:5]2[CH:4]=[CH:3][C:2]([NH:29][C:26]3[N:27]=[CH:28][N:24]([C:19]4[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=4[C:17]([F:31])([F:16])[F:30])[N:25]=3)=[CH:9][C:6]=2[C:7]#[N:8])[CH:14]=1

Participants

3

Reactant 2

HCID 623140051-(2-trifluoromethyl-phenyl)-1H-[1,2,4]triazol-3-ylamineHCID 669615175-bromo-2-(4-methyl-1H-imidazol-1-yl)benzonitrile

Product 1

HCID 462142422-(4-Methyl-imidazol-1-yl)-5-[1-(2-trifluoromethyl-phenyl)-1H-[1,2,4]triazol-3-ylamino]-benzonitrile

Procedure

Prepared in analogy to example 1b) starting with 5-bromo-2-(4-methyl-imidazol-1-yl)-benzonitrile and 1-(2-trifluoromethyl-phenyl)-1H-[1,2,4]triazol-3-ylamine. The title compound was obtained as a brownish solid (Yield=77%). MS ISP (m/e): 410.2 (100) [(M+H)+].

Workup

  1. customPrepared in analogy to example 1b)

Sources & evidence

ORD record
ord-abf4f683a42d42c98d09e9311d29bbe6
Source dataset
uspto-grants-2012_10
Patent number
US08288403B2

Reaction notes

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