1,2,4-Oxadiazol-3-amine, 5-((2,6-dichlorophenyl)methyl)- → HCID 46216251, compound

HRID 2063655Notes

Reaction equation

HRID 2063655 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([N:10]2[CH:14]=[C:13]([CH3:15])[N:12]=[CH:11]2)=[C:6]([CH:9]=1)[C:7]#[N:8].[Cl:16][C:17]1[CH:29]=[CH:28][CH:27]=[C:26]([Cl:30])[C:18]=1[CH2:19][C:20]1[O:24][N:23]=[C:22]([NH2:25])[N:21]=1>>[Cl:30][C:26]1[CH:27]=[CH:28][CH:29]=[C:17]([Cl:16])[C:18]=1[CH2:19][C:20]1[O:24][N:23]=[C:22]([NH:25][C:2]2[CH:3]=[CH:4][C:5]([N:10]3[CH:14]=[C:13]([CH3:15])[N:12]=[CH:11]3)=[C:6]([CH:9]=2)[C:7]#[N:8])[N:21]=1

Participants

3

Reactant 2

HCID 27431271,2,4-Oxadiazol-3-amine, 5-((2,6-dichlorophenyl)methyl)-HCID 669615175-bromo-2-(4-methyl-1H-imidazol-1-yl)benzonitrile

Product 1

HCID 46216251HCID 46216251, compound

Procedure

Prepared in analogy to example 1b) starting with 5-bromo-2-(4-methyl-imidazol-1-yl)-benzonitrile and 5-(2,6-dichloro-benzyl)-[1,2,4]oxadiazol-3-ylamine (M. J. Dimsdale, J. Heterocyclic Chem. 1981, 18, 37-41). The title compound was obtained as a white solid (Yield=17%). MS ISP (m/e): 425.1 & 426.9 (100 & 84) [(M+H)+].

Workup

  1. customPrepared in analogy to example 1b)

Sources & evidence

ORD record
ord-f03e957877bd44a0a8fa5415d1f47ea9
Source dataset
uspto-grants-2012_10
Patent number
US08288403B2

Reaction notes

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