1-[3-(trifluoromethyl)benzyl]-1H-1,2,4-triazol-3-amine → 2-(4-Methyl-imidazol-1-yl)-5-[1-(3-trifluoromethyl-benzyl)-1H-[1,2,4]triazol-3-ylamino]-benzonitrile

HRID 2063664Notes

Reaction equation

HRID 2063664 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([N:10]2[CH:14]=[C:13]([CH3:15])[N:12]=[CH:11]2)=[C:6]([CH:9]=1)[C:7]#[N:8].[F:16][C:17]([F:32])([F:31])[C:18]1[CH:19]=[C:20]([CH:28]=[CH:29][CH:30]=1)[CH2:21][N:22]1[CH:26]=[N:25][C:24]([NH2:27])=[N:23]1>>[CH3:15][C:13]1[N:12]=[CH:11][N:10]([C:5]2[CH:4]=[CH:3][C:2]([NH:27][C:24]3[N:25]=[CH:26][N:22]([CH2:21][C:20]4[CH:28]=[CH:29][CH:30]=[C:18]([C:17]([F:32])([F:16])[F:31])[CH:19]=4)[N:23]=3)=[CH:9][C:6]=2[C:7]#[N:8])[CH:14]=1

Participants

3

Reactant 2

HCID 70193291-[3-(trifluoromethyl)benzyl]-1H-1,2,4-triazol-3-amineHCID 669615175-bromo-2-(4-methyl-1H-imidazol-1-yl)benzonitrile

Product 1

HCID 462162542-(4-Methyl-imidazol-1-yl)-5-[1-(3-trifluoromethyl-benzyl)-1H-[1,2,4]triazol-3-ylamino]-benzonitrile

Procedure

Prepared in analogy to example 1b) starting with 5-bromo-2-(4-methyl-imidazol-1-yl)-benzonitrile and 1-(3-trifluoromethyl-benzyl)-1H-[1,2,4]triazol-3-ylamine. The title compound was obtained as a white solid (Yield=51%). MS ISP (m/e): 424.2 (100) [(M+H)+].

Workup

  1. customPrepared in analogy to example 1b)

Sources & evidence

ORD record
ord-91a1e4d0c5c1483dada3fa4a1620bdb1
Source dataset
uspto-grants-2012_10
Patent number
US08288403B2

Reaction notes

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