反应详情

温度

50 °C

A mixture of 3-benzyl-5-chloro-[1,2,4]thiadiazole (105 mg, 0.5 mmol) in ammonia (2 N in MeOH, 2 ml) was heated in a pressure tube at 50° C. for 5 h. The solvents were evaporated, the residue diluted with dichloromethane, the white solid (ammonium chloride) was filtered off, the filtrate was concentrated and then purified by silica gel chromatography using dichloromethane/methanol as eluent. The title compound was obtained as a light yellow liquid (40 mg, 41%). MS ISP (m/e): 192.1 (100) [(M+H)+].

1. customThe solvents were evaporated
2. additionthe residue diluted with dichloromethane
3. filtrationthe white solid (ammonium chloride) was filtered off
4. concentrationthe filtrate was concentrated
5. custompurified by silica gel chromatography