1-(Bromomethyl)-3-chlorobenzene → 1-[(3-Chlorophenyl)methyl]-1H-pyrazol-3-amine

HRID 2063671Notes

Reaction equation

HRID 2063671 reaction equation
[NH2:1][C:2]1[CH:6]=[CH:5][NH:4][N:3]=1.[Cl:7][C:8]1[CH:9]=[C:10]([CH:13]=[CH:14][CH:15]=1)[CH2:11]Br>>[Cl:7][C:8]1[CH:9]=[C:10]([CH:13]=[CH:14][CH:15]=1)[CH2:11][N:4]1[CH:5]=[CH:6][C:2]([NH2:1])=[N:3]1

Participants

3

Reactant 2

HCID 698381-(Bromomethyl)-3-chlorobenzeneHCID 178418806HCID 178418806, compound

Product 1

HCID 161950771-[(3-Chlorophenyl)methyl]-1H-pyrazol-3-amine

Procedure

Prepared in analogy to example 10a) starting with 3-amino-1H-pyrazole and 3-chlorobenzyl bromide. The title compound was obtained as a brown oil (Yield=11%). MS ISP (m/e): 208.0 (100) [(M+H)+].

Workup

  1. customPrepared in analogy to example 10a)

Sources & evidence

ORD record
ord-15c4f7f7676640d6b651245d0a244ceb
Source dataset
uspto-grants-2012_10
Patent number
US08288403B2

Reaction notes

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