5-bromo-2-(4-methyl-1H-imidazol-1-yl)benzonitrile → HCID 59324053, compound

HRID 2063681Notes

Reaction equation

HRID 2063681 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([N:10]2[CH:14]=[C:13]([CH3:15])[N:12]=[CH:11]2)=[C:6]([CH:9]=1)[C:7]#[N:8].[CH3:16][O:17][C:18](=[O:32])[C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([CH2:25][N:26]2[CH:30]=[N:29][C:28]([NH2:31])=[N:27]2)[CH:20]=1>>[CH3:16][O:17][C:18](=[O:32])[C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([CH2:25][N:26]2[CH:30]=[N:29][C:28]([NH:31][C:2]3[CH:3]=[CH:4][C:5]([N:10]4[CH:14]=[C:13]([CH3:15])[N:12]=[CH:11]4)=[C:6]([C:7]#[N:8])[CH:9]=3)=[N:27]2)[CH:20]=1

Participants

3

Reactant 2

HCID 669615175-bromo-2-(4-methyl-1H-imidazol-1-yl)benzonitrileHCID 67378047HCID 67378047, compound

Product 1

HCID 59324053HCID 59324053, compound

Procedure

Prepared in analogy to example 1b) starting with 5-bromo-2-(4-methyl-imidazol-1-yl)-benzonitrile and 3-(3-amino-[1,2,4]triazol-1-ylmethyl)-benzoic acid methyl ester. The title compound was obtained as a colorless solid (Yield=40%). MS ISP (m/e): 414.3 (100) [(M+H)+].

Workup

  1. customPrepared in analogy to example 1b)

Sources & evidence

ORD record
ord-e82631a9efd841ab8b55cf5e065592f9
Source dataset
uspto-grants-2012_10
Patent number
US08288403B2

Reaction notes

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