2,4-Dichlorobenzyl bromide → 1-(4-chlorobenzyl)-1H-pyrazol-3-amine

HRID 2063682Notes

Reaction equation

HRID 2063682 reaction equation
[NH2:1][C:2]1[CH:6]=[CH:5][NH:4][N:3]=1.Cl[C:8]1[CH:15]=[C:14]([Cl:16])[CH:13]=[CH:12][C:9]=1[CH2:10]Br>>[Cl:16][C:14]1[CH:15]=[CH:8][C:9]([CH2:10][N:4]2[CH:5]=[CH:6][C:2]([NH2:1])=[N:3]2)=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 109883732,4-Dichlorobenzyl bromideHCID 178418806HCID 178418806, compound

Product 1

HCID 6736901-(4-chlorobenzyl)-1H-pyrazol-3-amine

Procedure

Prepared in analogy to example 10a) starting with 3-amino-1H-pyrazole and 2,4-dichlorobenzyl bromide. The title compound was obtained as a light yellow solid (Yield=29%).

Workup

  1. customPrepared in analogy to example 10a)

Sources & evidence

ORD record
ord-81a77b9bd8f348b9a866e29628ca948a
Source dataset
uspto-grants-2012_10
Patent number
US08288403B2

Reaction notes

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